MolNFT v1 · #134434 · protein

Crystal structure of mycobacterium avium SERB2 mutant S275A/R279A at pH 6.6 with ethylene glycol bound at act- I domain

5T41 · Phosphoserine phosphatase: “Crystal structure of mycobacterium avium SERB2 mutant S275A/R279A at pH 6.6 with ethylene glycol bound at…”. X-ray diffraction, 1 ligand (MG), 2 pockets (best druggability 0.67). MolNFT v1 #134434 on…

PDB: 5T41
Type: protein
Length: 396 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Phosphoserine phosphatase
EC: 3.1.3.3
UniProt: A0QJI1
Ligands: MG
Pockets: 2 · best druggability 0.67

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Phosphoserine phosphatase (EC 3.1.3.3)	protein	396	41% helix, 28% strand	A0QJI1

Ligands and binding sites

MG · Magnesium ion · metal · chains A
EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	124	0.67	0.90	32	MG
2	87	0.45	0.81	19	empty

Compared structures

5T41 · Crystal structure of Mycobacterium avium SerB2 mutant S275A/R279A at pH 6.6 with ethylene… · the same entry in another collection · chain A against A, TM-score 1.00
A0QJI1 · AlphaFold monomer V2.0 prediction for phosphoserine phosphatase (A0QJI1) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0QJI1
Elsewhere: RCSB PDB 5T41 · PDBe 5T41 · UniProt A0QJI1

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