MolNFT v1 · #134429 · protein
Marburg virus VP30 bound to nucleoprotein
5T3W · Fusion protein of nucleoprotein and minor nucleoprotein VP30: “Marburg virus VP30 bound to nucleoprotein”. X-ray diffraction, 9 pockets (best druggability 0.75). MolNFT v1 #134429 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5T3W
- Type
- protein
- Length
- 1,096 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fusion protein of nucleoprotein and minor nucleoprotein VP30
- UniProt
- P27588, P35258
- Pockets
- 9 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 72% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H | Fusion protein of nucleoprotein and minor nucleoprotein VP30 | protein | 137 | 72% helix, 0% strand | P27588, P35258 |
Pockets
9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1011 | 0.75 | 0.78 | 89 | empty |
| 2 | 342 | 0.72 | 0.85 | 46 | empty |
| 3 | 328 | 0.72 | 0.85 | 43 | empty |
| 4 | 769 | 0.70 | 0.77 | 64 | empty |
| 5 | 274 | 0.57 | 0.77 | 23 | empty |
Interfaces
13 interfaces between chains.
- C–D · 3112 Ų buried · 33 hydrogen bonds · protein-protein
- A–B · 3086 Ų buried · 27 hydrogen bonds · protein-protein
- E–F · 3084 Ų buried · 29 hydrogen bonds · protein-protein
- G–H · 3075 Ų buried · 31 hydrogen bonds · protein-protein
- B–C · 445 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 5T3W · Marburg virus VP30 bound to nucleoprotein · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P27588
- Every structure of UniProt P35258
- Elsewhere: RCSB PDB 5T3W · PDBe 5T3W · UniProt P27588 · UniProt P35258
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