MolNFT v1 · #134401 · protein
Exploiting an asp-glu switch in glycogen synthase kinase 3 to design paralog selective inhibitors for use in acute myeloid leukemia
5T31: “Exploiting an asp-glu switch in glycogen synthase kinase 3 to design paralog selective inhibitors for use in…”. X-ray diffraction, 1 ligand (6VL). MolNFT v1 #134401 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5T31
- Type
- protein
- Length
- 669 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P49841
- Ligands
- 6VL
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 335 | — | P49841 |
| B | — | protein | 334 | — | P49841 |
Ligands and binding sites
- 6VL · (4~{S})-4-ethyl-7,7-dimethyl-4-phenyl-2,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P49841
- Elsewhere: RCSB PDB 5T31 · PDBe 5T31 · UniProt P49841
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