MolNFT v1 · #13440 · protein
Crystal structure of indole-3-glycerol phosphate synthase (igps) in complex with 1-(O-carboxyphenylamino)-1- deoxyribulose 5'-phosphate (cdrp)
1LBL: “Crystal structure of indole-3-glycerol phosphate synthase (igps) in complex with 1-(O-carboxyphenylamino)-1…”. X-ray diffraction, 1 ligand (137), 1 pocket (best druggability 0.71). MolNFT v1 #13440 on GenesisL1: 3D structure…
- PDB
- 1LBL
- Type
- protein
- Length
- 247 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Indole-3-glycerol phosphate synthase
- EC
- 4.1.1.48
- UniProt
- Q06121
- Ligands
- 137
- Pockets
- 1 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Indole-3-glycerol phosphate synthase (EC 4.1.1.48) | protein | 247 | 43% helix, 17% strand | Q06121 |
Ligands and binding sites
- 137 · 1-(O-carboxy-phenylamino)-1-deoxy-D-ribulose-5-phosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 131 | 0.71 | 0.91 | 31 | 137 |
Compared structures
- 1LBL · Crystal structure of indole-3-glycerol phosphate synthase (IGPS) in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
- Q06121 · AlphaFold monomer V2.0 prediction for indole-3-glycerol phosphate synthase (Q06121) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q06121
- Elsewhere: RCSB PDB 1LBL · PDBe 1LBL · UniProt Q06121
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