MolNFT v1 · #134394 · protein

Short chain DEHYDROGENASE/REDUCTASE family protein

5T2U · Oxidoreductase, short chain DEHYDROGENASE/REDUCTASE family…: “Short chain DEHYDROGENASE/REDUCTASE family protein”. X-ray diffraction, 1 ligand (NAP), 10 pockets (best druggability 0.86). MolNFT v1 #134394 on GenesisL1: 3D structure…

PDB: 5T2U
Type: protein
Length: 957 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Oxidoreductase, short chain DEHYDROGENASE/REDUCTASE family protein
UniProt: A0R723
Ligands: NAP
Pockets: 10 · best druggability 0.86

Structure

x-ray diffraction · 3 distinct chains · 49% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	Oxidoreductase, short chain DEHYDROGENASE/REDUCTASE family protein	protein	241	50% helix, 16% strand	A0R723
B	Oxidoreductase, short chain DEHYDROGENASE/REDUCTASE family protein	protein	235	46% helix, 17% strand	A0R723
D	Oxidoreductase, short chain DEHYDROGENASE/REDUCTASE family protein	protein	240	50% helix, 16% strand	A0R723

Ligands and binding sites

NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · 4 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	560	0.86	0.91	56	empty
2	432	0.80	0.88	49	NAP
3	422	0.79	0.88	48	NAP
4	403	0.78	0.87	47	NAP
5	649	0.75	0.81	73	NAP

Interfaces

6 interfaces between chains.

A–C · 1589 Å² buried · 16 hydrogen bonds · protein-protein
B–D · 1583 Å² buried · 14 hydrogen bonds · protein-protein
C–D · 1478 Å² buried · 12 hydrogen bonds · protein-protein
A–B · 1453 Å² buried · 13 hydrogen bonds · protein-protein
B–C · 224 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

5T2U · short chain dehydrogenase/reductase family protein · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0R723
Elsewhere: RCSB PDB 5T2U · PDBe 5T2U · UniProt A0R723

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.