MolNFT v1 · #134325 · protein

Crystal structure of a membrane protein

5T0O · Cmeb: “Crystal structure of a membrane protein”. X-ray diffraction, 20 pockets (best druggability 0.86). MolNFT v1 #134325 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5T0O
Type: protein
Length: 3,094 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cmeb
UniProt: Q8RTE4
Pockets: 20 · best druggability 0.86

Structure

x-ray diffraction · 3 distinct chains · 53% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cmeb	protein	1033	52% helix, 19% strand	Q8RTE4
B	Cmeb	protein	1026	52% helix, 20% strand	Q8RTE4
C	Cmeb	protein	1035	54% helix, 17% strand	Q8RTE4

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	782	0.86	0.89	107	empty
2	720	0.86	0.89	104	empty
3	597	0.84	0.89	81	empty
4	605	0.82	0.88	70	empty
5	950	0.81	0.83	82	empty

Interfaces

3 interfaces between chains.

A–B · 3154 Å² buried · 32 hydrogen bonds · protein-protein
A–C · 3149 Å² buried · 39 hydrogen bonds · protein-protein
B–C · 2822 Å² buried · 28 hydrogen bonds · protein-protein

Compared structures

5T0O · Crystal Structure of a membrane protein · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8RTE4
Elsewhere: RCSB PDB 5T0O · PDBe 5T0O · UniProt Q8RTE4

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