MolNFT v1 · #133914 · protein
Pandda analysis group deposition -- crystal structure of SARS-cov-2 NSP14 in complex with Z198195770
5SLF · Proofreading exoribonuclease NSP14: “Pandda analysis group deposition -- crystal structure of SARS-cov-2 NSP14 in complex with Z198195770”. X-ray diffraction, 3 ligands (LJA, ZN, PO4), 6 pockets (best druggability 0.70). MolNFT v1…
- PDB
- 5SLF
- Type
- protein
- Length
- 461 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proofreading exoribonuclease NSP14
- EC
- 3.1.13.-
- UniProt
- P0DTD1
- Ligands
- LJA, ZN, PO4
- Pockets
- 6 · best druggability 0.70
Structure
x-ray diffraction · 1 distinct chain · 30% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| D | Proofreading exoribonuclease NSP14 (EC 3.1.13.-) | protein | 461 | 30% helix, 21% strand | P0DTD1 |
Ligands and binding sites
- LJA · N-[3-(carbamoylamino)phenyl]acetamide · ligand · 2 copies · chains D
- ZN · Zinc ion · metal · 3 copies · chains D
- PO4 · Phosphate ion · ion · 2 copies · chains D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 434 | 0.70 | 0.81 | 33 | LJA |
| 2 | 188 | 0.49 | 0.76 | 29 | empty |
| 3 | 79 | 0.37 | 0.77 | 20 | LJA |
| 4 | 69 | 0.33 | 0.76 | 13 | empty |
| 5 | 69 | 0.30 | 0.74 | 16 | empty |
Compared structures
- 5SLF · PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with… · the same entry in another collection · chain D against D, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0DTD1
- Elsewhere: RCSB PDB 5SLF · PDBe 5SLF · UniProt P0DTD1
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.