MolNFT v1 · #133904 · protein

Pandda analysis group deposition -- crystal structure of SARS-cov-2 NSP14 in complex with Z32014663

5SL5 · Proofreading exoribonuclease NSP14: “Pandda analysis group deposition -- crystal structure of SARS-cov-2 NSP14 in complex with Z32014663”. X-ray diffraction, 3 ligands (WNV, ZN, PO4), 6 pockets (best druggability 0.68). MolNFT v1…

PDB: 5SL5
Type: protein
Length: 459 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Proofreading exoribonuclease NSP14
EC: 3.1.13.-
UniProt: P0DTD1
Ligands: WNV, ZN, PO4
Pockets: 6 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 29% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
D	Proofreading exoribonuclease NSP14 (EC 3.1.13.-)	protein	459	29% helix, 22% strand	P0DTD1

Ligands and binding sites

WNV · N,N,2,3-tetramethylbenzamide · ligand · chains D
ZN · Zinc ion · metal · 3 copies · chains D
PO4 · Phosphate ion · ion · 2 copies · chains D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	425	0.68	0.80	32	empty
2	184	0.48	0.76	30	empty
3	75	0.38	0.78	19	PO4, WNV
4	57	0.31	0.76	11	PO4
5	63	0.30	0.74	12	empty

Compared structures

5SL5 · PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with… · the same entry in another collection · chain D against D, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0DTD1
Elsewhere: RCSB PDB 5SL5 · PDBe 5SL5 · UniProt P0DTD1

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