MolNFT v1 · #13349 · protein
Crystal structure of DNA replication initiation factor
1L8Q · Chromosomal replication initiator protein dnaa: “Crystal structure of DNA replication initiation factor”. X-ray diffraction, 2 ligands (ADP, MG), 2 pockets (best druggability 0.56). MolNFT v1 #13349 on GenesisL1: 3D structure…
- PDB
- 1L8Q
- Type
- protein
- Length
- 321 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chromosomal replication initiator protein dnaa
- UniProt
- O66659
- Ligands
- ADP, MG
- Pockets
- 2 · best druggability 0.56
Structure
x-ray diffraction · 1 distinct chain · 61% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chromosomal replication initiator protein dnaa | protein | 321 | 61% helix, 7% strand | O66659 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 238 | 0.56 | 0.78 | 24 | MG, ADP |
| 2 | 160 | 0.46 | 0.76 | 25 | empty |
Modifications
Observed in the structure: 4 modified (engineered).
Compared structures
- 1L8Q · Crystal structure of DNA replication initiation factor · the same entry in another collection · chain A against A, TM-score 1.00
- O66659 · AlphaFold monomer V2.0 prediction for chromosomal replication initiator protein dnaa… · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O66659
- Elsewhere: RCSB PDB 1L8Q · PDBe 1L8Q · UniProt O66659
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