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MolNFT v1 · #1329 · protein

Crystal structures of peptide complexes of the amino- terminal SH2 domain of the syp tyrosine phosphatase

1AYC · Protein-tyrosine phosphatase syp (N-terminal SH2 domain): “Crystal structures of peptide complexes of the amino- terminal SH2 domain of the syp tyrosine phosphatase”. X-ray diffraction. MolNFT v1 #1329 on GenesisL1: 3D structure…

PDB
1AYC
Type
protein
Length
107 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Protein-tyrosine phosphatase syp (N-terminal SH2 domain); Peptide pdgfr-740
EC
3.1.3.48
UniProt
P35235, P05622

Structure

x-ray diffraction · 2 distinct chains · 19% helix, 29% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AProtein-tyrosine phosphatase syp (N-terminal SH2 domain) (EC 3.1.3.48)protein10020% helix, 30% strandP35235
PPeptide pdgfr-740protein70% helix, 14% strandP05622

Interfaces

1 interface between chains.

  • A–P · 447 Ų buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (phosphorylation).

Compared structures

  • 1AYC · Crystal structures of peptide complexes of the amino-terminal SH2 domain of the syp… · the same entry in another collection · chain A against A, TM-score 1.00
  • P35235 · AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 11… · a predicted model of the same protein · chain A against A, TM-score 0.94
  • P05622 · AlphaFold monomer V2.0 prediction for platelet-derived growth factor receptor beta… · a predicted model of the same protein · chain P against A, TM-score 0.51

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