MolNFT v1 · #13256 · protein

Crystal structure of a domain-opened mutant (R121D) of the human lactoferrin N-lobe refined from a merohedrally-twinned crystal form.

1L5T: “Crystal structure of a domain-opened mutant (R121D) of the human lactoferrin N-lobe refined from a…”. X-ray diffraction, 6 pockets (best druggability 0.44). MolNFT v1 #13256 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 1L5T
Type: protein
Length: 658 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lactoferrin
EC: 1.16.1.2
UniProt: P02788
Pockets: 6 · best druggability 0.44

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Lactoferrin (EC 1.16.1.2)	protein	329	36% helix, 20% strand	P02788

Pockets

6 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	133	0.44	0.77	23	empty
2	98	0.41	0.77	17	empty
3	123	0.41	0.75	20	empty
4	128	0.38	0.73	19	empty
5	66	0.38	0.79	17	empty

Modifications

Observed in the structure: 12 disulfide (disulfide).

Compared structures

1L5T · Crystal Structure of a Domain-Opened Mutant (R121D) of the Human Lactoferrin N-lobe… · the same entry in another collection · chain A against A, TM-score 1.00
P02788 · AlphaFold monomer V2.0 prediction for lactotransferrin (P02788) · a predicted model of the same protein · chain A against A, TM-score 0.66

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02788
Elsewhere: RCSB PDB 1L5T · PDBe 1L5T · UniProt P02788

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