MolNFT v1 · #131696 · protein

Crystal structure of human cathepsin-S with bound ligand

5QC5: “Crystal structure of human cathepsin-S with bound ligand”. X-ray diffraction, 1 ligand (BAJ). MolNFT v1 #131696 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5QC5
Type: protein
Length: 440 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P25774
Ligands: BAJ

Structure

x-ray diffraction · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	220	—	P25774
B	—	protein	220	—	P25774

Ligands and binding sites

BAJ · 1-[5-{1-[3-(4-tert-butylpiperidin-1-yl)propyl]-5-(methylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl}-2-(trifluoromethyl)phenyl]-N-[(4-fluorophenyl)methyl]methanamine · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

5QC5 · Crystal structure of human Cathepsin-S with bound ligand · the same entry in another collection · chain A against A, TM-score 1.00
P25774 · AlphaFold monomer V2.0 prediction for cathepsin S (P25774) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P25774
Elsewhere: RCSB PDB 5QC5 · PDBe 5QC5 · UniProt P25774

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.