MolNFT v1 · #131179 · protein
Pandda analysis group deposition -- crystal structure of SP100 after initial refinement with no ligand modelled (structure 50)
5PXQ · Nuclear autoantigen sp-100: “Pandda analysis group deposition -- crystal structure of SP100 after initial refinement with no ligand…”. X-ray diffraction, 1 ligand (ZN), 5 pockets (best druggability 0.59). MolNFT v1 #131179 on…
- PDB
- 5PXQ
- Type
- protein
- Length
- 355 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nuclear autoantigen sp-100
- UniProt
- P23497
- Ligands
- ZN
- Pockets
- 5 · best druggability 0.59
Structure
x-ray diffraction · 2 distinct chains · 49% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nuclear autoantigen sp-100 | protein | 178 | 50% helix, 6% strand | P23497 |
| B | Nuclear autoantigen sp-100 | protein | 177 | 49% helix, 6% strand | P23497 |
Ligands and binding sites
- ZN · Zinc ion · metal · 5 copies · chains A, B
- EDO · 1,2-ethanediol · additive · 2 copies · chains A, B
- MES · 2-(N-morpholino)-ethanesulfonic acid · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 224 | 0.59 | 0.80 | 26 | MES |
| 2 | 152 | 0.47 | 0.77 | 28 | EDO |
| 3 | 54 | 0.46 | 0.84 | 16 | empty |
| 4 | 102 | 0.37 | 0.75 | 16 | empty |
| 5 | 83 | 0.32 | 0.74 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 537 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 5PXQ · PanDDA analysis group deposition -- Crystal Structure of SP100 after initial refinement… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23497
- Elsewhere: RCSB PDB 5PXQ · PDBe 5PXQ · UniProt P23497
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