MolNFT v1 · #13084 · protein
Crystal structure of the bacillus stearothermophilus anti-sigma factor spoiiab with the sporulation sigma factor sigmaf
1L0O · Anti-sigma F factor: “Crystal structure of the bacillus stearothermophilus anti-sigma factor spoiiab with the sporulation sigma…”. X-ray diffraction, 2 ligands (ADP, MG), 4 pockets (best druggability 0.70). MolNFT v1 #13084 on…
- PDB
- 1L0O
- Type
- protein
- Length
- 339 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Anti-sigma F factor; Sigma factor
- UniProt
- O32727, O32728
- Ligands
- ADP, MG
- Pockets
- 4 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 49% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Anti-sigma F factor | protein | 141 | 40% helix, 24% strand | O32727 |
| C | Sigma factor | protein | 57 | 74% helix, 2% strand | O32728 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · 2 copies · chains A, B
- MG · Magnesium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 183 | 0.70 | 0.88 | 36 | MG, ADP |
| 2 | 224 | 0.65 | 0.84 | 41 | MG, ADP |
| 3 | 158 | 0.48 | 0.77 | 21 | empty |
| 4 | 61 | 0.33 | 0.76 | 10 | empty |
Interfaces
3 interfaces between chains.
- A–B · 807 Ų buried · 23 hydrogen bonds · protein-protein
- B–C · 693 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 471 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 1L0O · Crystal Structure of the Bacillus stearothermophilus Anti-Sigma Factor SpoIIAB with the… · the same entry in another collection · chain A against A, TM-score 1.00
- O32727 · AlphaFold monomer V2.0 prediction for anti-sigma F factor (O32727) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O32727
- Every structure of UniProt O32728
- Elsewhere: RCSB PDB 1L0O · PDBe 1L0O · UniProt O32727 · UniProt O32728
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