MolNFT v1 · #13059 · protein
Downstream regulator tank binds to the CD40 recognition site on TRAF3
1KZZ · TNF receptor associated factor 3: “Downstream regulator tank binds to the CD40 recognition site on TRAF3”. X-ray diffraction, 1 pocket (best druggability 0.30). MolNFT v1 #13059 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 1KZZ
- Type
- protein
- Length
- 203 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TNF receptor associated factor 3; Traf family member-associated nf-kappa-B activator
- UniProt
- Q13114, Q92844
- Pockets
- 1 · best druggability 0.30
Structure
x-ray diffraction · 2 distinct chains · 24% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TNF receptor associated factor 3 | protein | 192 | 26% helix, 24% strand | Q13114 |
| B | Traf family member-associated nf-kappa-B activator | protein | 11 | 0% helix, 9% strand | Q92844 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 80 | 0.30 | 0.72 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 505 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 1KZZ · Downstream regulator tank binds to the CD40 recognition site on TRAF3 · the same entry in another collection · chain A against A, TM-score 1.00
- Q13114 · AlphaFold monomer V2.0 prediction for TNF receptor-associated factor 3 (Q13114) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q92844 · AlphaFold monomer V2.0 prediction for traf family member-associated nf-kappa-B activator… · a predicted model of the same protein · chain B against A, TM-score 0.32
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13114
- Every structure of UniProt Q92844
- Elsewhere: RCSB PDB 1KZZ · PDBe 1KZZ · UniProt Q13114 · UniProt Q92844
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