MolNFT v1 · #1303 · protein
Heparin-linked biologically-active dimer of fibroblast growth factor
1AXM · Acidic fibroblast growth factor: “Heparin-linked biologically-active dimer of fibroblast growth factor”. X-ray diffraction, 2 ligands (SGN, IDS). MolNFT v1 #1303 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1AXM
- Type
- protein
- Length
- 770 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Acidic fibroblast growth factor
- UniProt
- P05230
- Ligands
- SGN, IDS
Structure
x-ray diffraction · 4 distinct chains · 9% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Acidic fibroblast growth factor | protein | 130 | 7% helix, 40% strand | P05230 |
| B, D | Acidic fibroblast growth factor | protein | 127 | 9% helix, 42% strand | P05230 |
| C | Acidic fibroblast growth factor | protein | 128 | 9% helix, 41% strand | P05230 |
| E, F | Acidic fibroblast growth factor | protein | 129 | 9% helix, 40% strand | P05230 |
Ligands and binding sites
- SGN · 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose · sugar · 8 copies · chains A, B, C, E, D, F
- IDS · 2-O-sulfo-alpha-L-idopyranuronic acid · sugar · 7 copies · chains A, B, C, E, F, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Modifications
Observed in the structure: 6 modified (engineered).
Compared structures
- 1AXM · Heparin-linked biologically-active dimer of fibroblast growth factor · the same entry in another collection · chain F against F, TM-score 1.00
- P05230 · AlphaFold monomer V2.0 prediction for fibroblast growth factor 1 (P05230) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05230
- Elsewhere: RCSB PDB 1AXM · PDBe 1AXM · UniProt P05230
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