MolNFT v1 · #129912 · protein

Structure of calcium-free MTMEM16A chloride channel at 4.06 a resolution

5OYG · Anoctamin-1: “Structure of calcium-free MTMEM16A chloride channel at 4.06 a resolution”. Electron microscopy, 20 pockets (best druggability 0.82). MolNFT v1 #129912 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5OYG
Type: protein
Length: 1,418 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Anoctamin-1
UniProt: Q8BHY3
Pockets: 20 · best druggability 0.82

Structure

electron microscopy · 1 distinct chain · 56% helix, 6% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Anoctamin-1	protein	709	56% helix, 6% strand	Q8BHY3

Pockets

20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	659	0.82	0.86	66	empty
2	657	0.82	0.86	63	empty
3	1104	0.78	0.80	94	empty
4	1083	0.78	0.80	90	empty
5	811	0.74	0.78	69	empty

Interfaces

1 interface between chains.

A–B · 856 Å² buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 disulfide (disulfide).

Compared structures

5OYG · Structure of calcium-free mTMEM16A chloride channel at 4.06 A resolution · the same entry in another collection · chain A against A, TM-score 1.00
Q8BHY3 · AlphaFold monomer V2.0 prediction for anoctamin-1 (Q8BHY3) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8BHY3
Elsewhere: RCSB PDB 5OYG · PDBe 5OYG · UniProt Q8BHY3

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