MolNFT v1 · #129859 · protein
Inside-out fmdv A10 capsid
5OWX · Genome polyprotein: “Inside-out fmdv A10 capsid”. Electron microscopy, 16 pockets (best druggability 0.77). MolNFT v1 #129859 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5OWX
- Type
- protein
- Length
- 564 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Genome polyprotein
- EC
- 3.4.22.46, 3.6.1.15, 3.4.22.28, 2.7.7.48
- UniProt
- P03306
- Pockets
- 16 · best druggability 0.77
Structure
electron microscopy · 3 distinct chains · 9% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| 1 | Genome polyprotein (EC 3.4.22.46, 3.6.1.15, 3.4.22.28, 2.7.7.48) | protein | 161 | 12% helix, 24% strand | P03306 |
| 2 | Genome polyprotein (EC 3.4.22.46, 3.6.1.15, 3.4.22.28, 2.7.7.48) | protein | 182 | 10% helix, 33% strand | P03306 |
| 3 | Genome polyprotein (EC 3.4.22.46, 3.6.1.15, 3.4.22.28, 2.7.7.48) | protein | 221 | 6% helix, 12% strand | P03306 |
Pockets
16 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 625 | 0.77 | 0.82 | 74 | empty |
| 2 | 240 | 0.74 | 0.88 | 50 | empty |
| 3 | 212 | 0.70 | 0.87 | 53 | empty |
| 4 | 140 | 0.70 | 0.90 | 36 | empty |
| 5 | 135 | 0.69 | 0.89 | 28 | empty |
Interfaces
3 interfaces between chains.
- 1–3 · 2470 Ų buried · 25 hydrogen bonds · protein-protein
- 2–3 · 1168 Ų buried · 9 hydrogen bonds · protein-protein
- 1–2 · 1037 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 5OWX · Inside-out FMDV A10 capsid · the same entry in another collection · chain 1 against 1, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03306
- Elsewhere: RCSB PDB 5OWX · PDBe 5OWX · UniProt P03306
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