MolNFT v1 · #129813 · protein

Crystal structure of fiv reverse transcriptase

5OVN · Pol protein: “Crystal structure of fiv reverse transcriptase”. X-ray diffraction, 12 pockets (best druggability 0.78). MolNFT v1 #129813 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5OVN
Type: protein
Length: 935 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pol protein
UniProt: Q66972
Pockets: 12 · best druggability 0.78

Structure

x-ray diffraction · 2 distinct chains · 31% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Pol protein	protein	530	30% helix, 21% strand	Q66972
B	Pol protein	protein	405	33% helix, 19% strand	Q66972

Pockets

12 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	595	0.78	0.84	83	empty
2	797	0.72	0.78	68	empty
3	119	0.71	0.92	28	empty
4	296	0.65	0.81	45	empty
5	62	0.56	0.89	17	empty

Interfaces

1 interface between chains.

A–B · 2636 Å² buried · 32 hydrogen bonds · protein-protein

Compared structures

5OVN · Crystal Structure of FIV Reverse Transcriptase · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q66972
Elsewhere: RCSB PDB 5OVN · PDBe 5OVN · UniProt Q66972

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