MolNFT v1 · #129711 · protein + RNA

Structure of ksrp in context of leishmania donovani 80S

5OSG · RNA binding protein, putative: “Structure of ksrp in context of leishmania donovani 80S”. Electron microscopy, 8 pockets (best druggability 0.82). MolNFT v1 #129711 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5OSG
Type: protein + RNA
Length: 294 residues
Chains: 3
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA binding protein, putative; 18S rRNA; 40S ribosomal protein S6
UniProt: E9BNI3, Q9NE83
Pockets: 8 · best druggability 0.82

Structure

electron microscopy · 3 distinct chains · 37% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
h	RNA binding protein, putative	protein	173	30% helix, 17% strand	E9BNI3
2	18S rRNA	rna	88	—	—
P	40S ribosomal protein S6	protein	33	76% helix, 0% strand	Q9NE83

Pockets

8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	752	0.82	0.86	50	empty
2	698	0.74	0.81	42	empty
3	290	0.62	0.80	22	empty
4	265	0.55	0.77	26	empty
5	76	0.45	0.82	18	empty

Interfaces

3 interfaces between chains.

h–2 · 2671 Å² buried · 67 hydrogen bonds · protein-nucleic
2–P · 828 Å² buried · 25 hydrogen bonds · protein-nucleic
h–P · 218 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

5OSG · Structure of KSRP in context of Leishmania donovani 80S · the same entry in another collection · chain h against h, TM-score 1.00
Q9NE83 · AlphaFold monomer V2.0 prediction for 40S ribosomal protein S6 (Q9NE83) · a predicted model of the same protein · chain P against A, TM-score 0.61

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt E9BNI3
Every structure of UniProt Q9NE83
Elsewhere: RCSB PDB 5OSG · PDBe 5OSG · UniProt E9BNI3 · UniProt Q9NE83

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.