MolNFT v1 · #129655 · protein
Crystal structure of the S. cerevisiae condensin YCG1-BRN1 subcomplex
5OQQ · Condensin complex subunit 3: “Crystal structure of the S. cerevisiae condensin YCG1-BRN1 subcomplex”. X-ray diffraction, 16 pockets (best druggability 0.69). MolNFT v1 #129655 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 5OQQ
- Type
- protein
- Length
- 1,776 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Condensin complex subunit 3; Condensin complex subunit 2
- UniProt
- Q06680, P38170
- Pockets
- 16 · best druggability 0.69
Structure
x-ray diffraction · 4 distinct chains · 69% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Condensin complex subunit 3 | protein | 792 | 74% helix, 1% strand | Q06680 |
| B | Condensin complex subunit 3 | protein | 824 | 72% helix, 0% strand | Q06680 |
| D | Condensin complex subunit 2 | protein | 96 | 30% helix, 6% strand | P38170 |
| C | Condensin complex subunit 2 | protein | 64 | 16% helix, 6% strand | P38170 |
Pockets
16 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 62 | 0.69 | 0.95 | 20 | empty |
| 2 | 127 | 0.69 | 0.90 | 25 | empty |
| 3 | 381 | 0.67 | 0.80 | 44 | empty |
| 4 | 577 | 0.67 | 0.77 | 42 | empty |
| 5 | 78 | 0.46 | 0.82 | 14 | empty |
Interfaces
4 interfaces between chains.
- B–D · 3881 Ų buried · 51 hydrogen bonds · protein-protein
- A–C · 2901 Ų buried · 41 hydrogen bonds · protein-protein
- A–B · 998 Ų buried · 8 hydrogen bonds · protein-protein
- A–D · 328 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 5OQQ · Crystal structure of the S. cerevisiae condensin Ycg1-Brn1 subcomplex · the same entry in another collection · chain C against C, TM-score 1.00
- Q06680 · AlphaFold monomer V2.0 prediction for condensin complex subunit 3 (Q06680) · a predicted model of the same protein · chain A against A, TM-score 0.99
- P38170 · AlphaFold monomer V2.0 prediction for condensin complex subunit 2 (P38170) · a predicted model of the same protein · chain D against A, TM-score 0.75
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q06680
- Every structure of UniProt P38170
- Elsewhere: RCSB PDB 5OQQ · PDBe 5OQQ · UniProt Q06680 · UniProt P38170
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