MolNFT v1 · #129592 · protein

Designed ankyrin repeat protein (darpin) etvd-1 in complex with lysozyme

5OOV · Darpin etvd-1: “Designed ankyrin repeat protein (darpin) etvd-1 in complex with lysozyme”. X-ray diffraction, 1 pocket (best druggability 0.47). MolNFT v1 #129592 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5OOV
Type: protein
Length: 286 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Darpin etvd-1; Lysozyme C
EC: 3.2.1.17
UniProt: P00698
Pockets: 1 · best druggability 0.47

Structure

x-ray diffraction · 2 distinct chains · 48% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Darpin etvd-1	protein	157	54% helix, 0% strand	—
B	Lysozyme C (EC 3.2.1.17)	protein	129	40% helix, 11% strand	P00698

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	147	0.47	0.77	27	empty

Interfaces

1 interface between chains.

A–B · 1016 Å² buried · 10 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

5OOV · Designed Ankyrin Repeat Protein (DARPin) ETVD-1 in complex with Lysozyme · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00698
Elsewhere: RCSB PDB 5OOV · PDBe 5OOV · UniProt P00698

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