MolNFT v1 · #129413 · protein
Sirtuin 4 from xenopus tropicalis in complex with thioacetyl-ADP- ribose
5OJN · NAD-dependent protein deacylase: “Sirtuin 4 from xenopus tropicalis in complex with thioacetyl-ADP- ribose”. X-ray diffraction, 2 ligands (9X8, ZN), 2 pockets (best druggability 0.79). MolNFT v1 #129413 on GenesisL1: 3D structure…
- PDB
- 5OJN
- Type
- protein
- Length
- 272 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NAD-dependent protein deacylase
- EC
- 3.5.1.-
- UniProt
- Q28CB4
- Ligands
- 9X8, ZN
- Pockets
- 2 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NAD-dependent protein deacylase (EC 3.5.1.-) | protein | 272 | 42% helix, 16% strand | Q28CB4 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 806 | 0.79 | 0.83 | 72 | 9X8 |
| 2 | 100 | 0.35 | 0.74 | 20 | empty |
Compared structures
- 5OJN · Sirtuin 4 from Xenopus tropicalis in complex with thioacetyl-ADP-ribose · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q28CB4
- Elsewhere: RCSB PDB 5OJN · PDBe 5OJN · UniProt Q28CB4
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