MolNFT v1 · #129260 · protein
Crystal structure of leishmania major fructose-1,6-bisphosphatase in apo form.
5OEZ · Fbp protein: “Crystal structure of leishmania major fructose-1,6-bisphosphatase in apo form.”. X-ray diffraction, 16 pockets (best druggability 0.82). MolNFT v1 #129260 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5OEZ
- Type
- protein
- Length
- 1,246 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fbp protein
- EC
- 3.1.3.11
- UniProt
- O97193
- Pockets
- 16 · best druggability 0.82
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, D | Fbp protein (EC 3.1.3.11) | protein | 311 | 39% helix, 26% strand | O97193 |
| C | Fbp protein (EC 3.1.3.11) | protein | 313 | 40% helix, 26% strand | O97193 |
Pockets
16 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 311 | 0.82 | 0.92 | 51 | empty |
| 2 | 113 | 0.78 | 0.97 | 30 | empty |
| 3 | 75 | 0.74 | 0.98 | 24 | empty |
| 4 | 241 | 0.66 | 0.84 | 43 | empty |
| 5 | 258 | 0.64 | 0.82 | 46 | empty |
Interfaces
6 interfaces between chains.
- A–B · 2024 Ų buried · 29 hydrogen bonds · protein-protein
- C–D · 1995 Ų buried · 30 hydrogen bonds · protein-protein
- B–C · 1390 Ų buried · 18 hydrogen bonds · protein-protein
- A–D · 1244 Ų buried · 17 hydrogen bonds · protein-protein
- B–D · 80 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 5OEZ · Crystal structure of Leishmania major fructose-1,6-bisphosphatase in apo form. · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O97193
- Elsewhere: RCSB PDB 5OEZ · PDBe 5OEZ · UniProt O97193
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