MolNFT v1 · #128732 · protein
Crystal structure of udp-glucose pyrophosphorylase from leishmania major in complex with phenylalanine
5NZK: “Crystal structure of udp-glucose pyrophosphorylase from leishmania major in complex with phenylalanine”. X-ray diffraction, 2 ligands (PHE, SO4), 3 pockets (best druggability 0.67). MolNFT v1 #128732 on GenesisL1: 3D structure…
- PDB
- 5NZK
- Type
- protein
- Length
- 483 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Udp-glucose pyrophosphorylase
- EC
- 2.7.7.9
- UniProt
- Q4QDU3
- Ligands
- PHE, SO4
- Pockets
- 3 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 33% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Udp-glucose pyrophosphorylase (EC 2.7.7.9) | protein | 483 | 33% helix, 27% strand | Q4QDU3 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 679 | 0.67 | 0.76 | 84 | empty |
| 2 | 386 | 0.64 | 0.78 | 46 | empty |
| 3 | 55 | 0.30 | 0.75 | 13 | empty |
Compared structures
- 5NZK · Crystal structure of UDP-glucose pyrophosphorylase from Leishmania major in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q4QDU3
- Elsewhere: RCSB PDB 5NZK · PDBe 5NZK · UniProt Q4QDU3
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