MolNFT v1 · #128548 · protein
Crystal structure of the human bromodomain of EP300 bound to the inhibitor xdm-cbp
5NU5: “Crystal structure of the human bromodomain of EP300 bound to the inhibitor xdm-cbp”. X-ray diffraction, 1 ligand (99E). MolNFT v1 #128548 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5NU5
- Type
- protein
- Length
- 232 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q09472
- Ligands
- 99E
Structure
x-ray diffraction · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | — | protein | 116 | — | Q09472 |
Ligands and binding sites
- 99E · ~{N}-[[2,8-bis(oxidanyl)naphthalen-1-yl]methyl]-4-ethanoyl-3-ethyl-5-methyl-1~{H}-pyrrole-2-carboxamide · ligand · 2 copies · chains A, B
- EDO · 1,2-ethanediol · additive · 5 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5NU5 · Crystal structure of the human bromodomain of EP300 bound to the inhibitor XDM-CBP · the same entry in another collection · chain A against A, TM-score 1.00
- Q09472 · AlphaFold monomer V2.0 prediction for histone acetyltransferase P300 (Q09472) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q09472
- Elsewhere: RCSB PDB 5NU5 · PDBe 5NU5 · UniProt Q09472
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