MolNFT v1 · #128513 · protein

Apo structure of leucyl aminopeptidase from trypanosoma brucei

5NSK · Aminopeptidase, putative: “Apo structure of leucyl aminopeptidase from trypanosoma brucei”. X-ray diffraction, 20 pockets (best druggability 0.75). MolNFT v1 #128513 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5NSK
Type: protein
Length: 3,039 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Aminopeptidase, putative
UniProt: Q385B0
Pockets: 20 · best druggability 0.75

Structure

x-ray diffraction · 3 distinct chains · 38% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Aminopeptidase, putative	protein	507	38% helix, 22% strand	Q385B0
B, C, D, E	Aminopeptidase, putative	protein	506	39% helix, 22% strand	Q385B0
F	Aminopeptidase, putative	protein	508	38% helix, 22% strand	Q385B0

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	970	0.75	0.78	120	empty
2	381	0.71	0.83	56	empty
3	273	0.69	0.84	36	empty
4	253	0.68	0.84	34	empty
5	269	0.68	0.84	36	empty

Interfaces

12 interfaces between chains.

B–C · 1631 Å² buried · 37 hydrogen bonds · protein-protein
D–F · 1585 Å² buried · 41 hydrogen bonds · protein-protein
A–E · 1573 Å² buried · 37 hydrogen bonds · protein-protein
E–F · 1036 Å² buried · 19 hydrogen bonds · protein-protein
A–D · 1032 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

5NSK · apo Structure of Leucyl aminopeptidase from Trypanosoma brucei · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q385B0
Elsewhere: RCSB PDB 5NSK · PDBe 5NSK · UniProt Q385B0

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