MolNFT v1 · #128377 · protein
CA2+-induced movement of tropomyosin on native cardiac thin filaments - "blocked" state
5NOG · Cardiac muscle alpha actin 1: “CA2+-induced movement of tropomyosin on native cardiac thin filaments - "blocked" state”. Electron microscopy, 2 ligands (ADP, MG), 20 pockets (best druggability 0.78). MolNFT v1 #128377 on GenesisL1…
- PDB
- 5NOG
- Type
- protein
- Length
- 2,105 residues
- Chains
- 7
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cardiac muscle alpha actin 1; Cardiac alpha tropomyosin
- UniProt
- B6VNT8
- Ligands
- ADP, MG
- Pockets
- 20 · best druggability 0.78
Structure
electron microscopy · 2 distinct chains · 48% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | Cardiac muscle alpha actin 1 | protein | 367 | 30% helix, 16% strand | B6VNT8 |
| F, G | Cardiac alpha tropomyosin | protein | 135 | 99% helix, 0% strand | — |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · 5 copies · chains A, B, C, D, E
- MG · Magnesium ion · metal · 5 copies · chains A, B, C, D, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 314 | 0.78 | 0.89 | 55 | ADP, MG |
| 2 | 921 | 0.77 | 0.80 | 61 | empty |
| 3 | 406 | 0.77 | 0.86 | 67 | ADP, MG |
| 4 | 973 | 0.76 | 0.79 | 63 | empty |
| 5 | 1099 | 0.76 | 0.79 | 73 | empty |
Interfaces
9 interfaces between chains.
- F–G · 1364 Ų buried · 0 hydrogen bonds · protein-protein
- D–E · 1258 Ų buried · 17 hydrogen bonds · protein-protein
- A–B · 1251 Ų buried · 15 hydrogen bonds · protein-protein
- A–C · 1239 Ų buried · 15 hydrogen bonds · protein-protein
- A–E · 697 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 modified (methylation).
Compared structures
- 5NOG · Ca2+-induced Movement of Tropomyosin on Native Cardiac Thin Filaments - "Blocked" state · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B6VNT8
- Elsewhere: RCSB PDB 5NOG · PDBe 5NOG · UniProt B6VNT8
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