MolNFT v1 · #128360 · protein

Crystal structure of human ODA16

5NNZ · Dynein assembly factor with wdr repeat domains 1: “Crystal structure of human ODA16”. X-ray diffraction, 4 pockets (best druggability 0.78). MolNFT v1 #128360 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5NNZ
Type: protein
Length: 670 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Dynein assembly factor with wdr repeat domains 1
UniProt: Q8N136
Pockets: 4 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 1% helix, 53% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B, A	Dynein assembly factor with wdr repeat domains 1	protein	335	1% helix, 53% strand	Q8N136

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	962	0.78	0.80	61	empty
2	1039	0.77	0.79	64	empty
3	242	0.56	0.78	38	empty
4	106	0.36	0.74	18	empty

Interfaces

1 interface between chains.

B–A · 259 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

5NNZ · Crystal structure of human ODA16 · the same entry in another collection · chain B against B, TM-score 1.00
Q8N136 · AlphaFold monomer V2.0 prediction for dynein assembly factor with wdr repeat domains 1… · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8N136
Elsewhere: RCSB PDB 5NNZ · PDBe 5NNZ · UniProt Q8N136

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