MolNFT v1 · #128340 · protein
Crystal structure of the first bromodomain of human BRD4 in complex with an acetylated BAZ1B peptide (K221AC)
5NNF · Bromodomain-containing protein 4: “Crystal structure of the first bromodomain of human BRD4 in complex with an acetylated BAZ1B peptide (K221AC)”. X-ray diffraction. MolNFT v1 #128340 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5NNF
- Type
- protein
- Length
- 134 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bromodomain-containing protein 4; FLPH(ALY)YDVKL
- UniProt
- O60885
Structure
x-ray diffraction · 2 distinct chains · 51% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Bromodomain-containing protein 4 | protein | 126 | 52% helix, 0% strand | O60885 |
| B | FLPH(ALY)YDVKL | protein | 8 | 38% helix, 0% strand | — |
Interfaces
1 interface between chains.
- A–B · 599 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (acetylation).
Compared structures
- 5NNF · Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated… · the same entry in another collection · chain A against A, TM-score 1.00
- O60885 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 4 (O60885) · a predicted model of the same protein · chain A against A, TM-score 0.83
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O60885
- Elsewhere: RCSB PDB 5NNF · PDBe 5NNF · UniProt O60885
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