MolNFT v1 · #12829 · protein
Structure of the large fkbp-like protein, FKBP51, involved in steroid receptor complexes
1KT0 · 51 kda FK506-binding protein: “Structure of the large fkbp-like protein, FKBP51, involved in steroid receptor complexes”. X-ray diffraction, 1 ligand (SO4), 4 pockets (best druggability 0.44). MolNFT v1 #12829 on GenesisL1: 3D…
- PDB
- 1KT0
- Type
- protein
- Length
- 357 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 51 kda FK506-binding protein
- EC
- 5.2.1.8
- UniProt
- Q13451
- Ligands
- SO4
- Pockets
- 4 · best druggability 0.44
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 51 kda FK506-binding protein (EC 5.2.1.8) | protein | 357 | 43% helix, 25% strand | Q13451 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 135 | 0.44 | 0.77 | 20 | empty |
| 2 | 57 | 0.37 | 0.78 | 13 | empty |
| 3 | 113 | 0.37 | 0.74 | 20 | empty |
| 4 | 73 | 0.30 | 0.73 | 12 | empty |
Compared structures
- 1KT0 · Structure of the Large FKBP-like Protein, FKBP51, Involved in Steroid Receptor Complexes · the same entry in another collection · chain A against A, TM-score 1.00
- Q13451 · AlphaFold monomer V2.0 prediction for peptidyl-prolyl cis-trans isomerase FKBP5 (Q13451) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13451
- Elsewhere: RCSB PDB 1KT0 · PDBe 1KT0 · UniProt Q13451
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