MolNFT v1 · #128215 · protein

Flavivirus NS5 domain

5NJU · Genome polyprotein: “Flavivirus NS5 domain”. X-ray diffraction, 2 ligands (SAH, MG), 4 pockets (best druggability 0.65). MolNFT v1 #128215 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5NJU
Type: protein
Length: 506 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Genome polyprotein
UniProt: A0A146CJG7
Ligands: SAH, MG
Pockets: 4 · best druggability 0.65

Structure

x-ray diffraction · 2 distinct chains · 36% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Genome polyprotein	protein	260	37% helix, 17% strand	A0A146CJG7
B	Genome polyprotein	protein	246	36% helix, 17% strand	A0A146CJG7

Ligands and binding sites

SAH · S-adenosyl-L-homocysteine · ligand · 2 copies · chains A, B
MG · Magnesium ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	346	0.65	0.80	41	empty
2	495	0.64	0.76	44	SAH
3	404	0.64	0.78	55	SAH
4	98	0.39	0.76	17	empty

Interfaces

1 interface between chains.

A–B · 580 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

5NJU · Flavivirus NS5 domain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A146CJG7
Elsewhere: RCSB PDB 5NJU · PDBe 5NJU · UniProt A0A146CJG7

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.