MolNFT v1 · #128036 · protein
Crystal structure of the soluble domain of lipc, a membrane fusion protein of a type I secretion system
5NEN · Lipase C: “Crystal structure of the soluble domain of lipc, a membrane fusion protein of a type I secretion system”. X-ray diffraction, 6 pockets (best druggability 0.78). MolNFT v1 #128036 on GenesisL1: 3D structure, binding sites…
- PDB
- 5NEN
- Type
- protein
- Length
- 479 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lipase C
- UniProt
- Q54457
- Pockets
- 6 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 73% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Lipase C | protein | 266 | 67% helix, 6% strand | Q54457 |
| B | Lipase C | protein | 213 | 81% helix, 0% strand | Q54457 |
Pockets
6 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 149 | 0.78 | 0.94 | 28 | empty |
| 2 | 535 | 0.70 | 0.80 | 52 | empty |
| 3 | 564 | 0.70 | 0.79 | 61 | empty |
| 4 | 451 | 0.70 | 0.81 | 44 | empty |
| 5 | 287 | 0.53 | 0.75 | 42 | empty |
Interfaces
1 interface between chains.
- A–B · 1706 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
- 5NEN · Crystal structure of the soluble domain of LipC, a membrane fusion protein of a type I… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q54457
- Elsewhere: RCSB PDB 5NEN · PDBe 5NEN · UniProt Q54457
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