MolNFT v1 · #127978 · protein
The crystal structure of N-acetylmannosamine kinase in fusobacterium nucleatum
5NCK: “The crystal structure of N-acetylmannosamine kinase in fusobacterium nucleatum”. X-ray diffraction, 4 pockets (best druggability 0.69). MolNFT v1 #127978 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5NCK
- Type
- protein
- Length
- 582 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- N-acetylmannosamine kinase
- EC
- 2.7.1.60
- UniProt
- Q8RDN7
- Pockets
- 4 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 46% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | N-acetylmannosamine kinase (EC 2.7.1.60) | protein | 291 | 46% helix, 23% strand | Q8RDN7 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 641 | 0.69 | 0.78 | 60 | empty |
| 2 | 521 | 0.64 | 0.77 | 59 | empty |
| 3 | 205 | 0.47 | 0.75 | 34 | empty |
| 4 | 103 | 0.42 | 0.77 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 1560 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 5NCK · The Crystal Structure of N-acetylmannosamine kinase in Fusobacterium nucleatum · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8RDN7
- Elsewhere: RCSB PDB 5NCK · PDBe 5NCK · UniProt Q8RDN7
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