MolNFT v1 · #127975 · protein
Grie apo form
5NCH · Leucine hydroxylase: “Grie apo form”. X-ray diffraction, 8 pockets (best druggability 0.68). MolNFT v1 #127975 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5NCH
- Type
- protein
- Length
- 499 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Leucine hydroxylase
- UniProt
- A0A0E3URV8
- Pockets
- 8 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 29% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Leucine hydroxylase | protein | 246 | 29% helix, 25% strand | A0A0E3URV8 |
| B | Leucine hydroxylase | protein | 253 | 30% helix, 25% strand | A0A0E3URV8 |
Pockets
8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 498 | 0.68 | 0.79 | 40 | empty |
| 2 | 310 | 0.62 | 0.79 | 33 | empty |
| 3 | 88 | 0.39 | 0.77 | 22 | empty |
| 4 | 97 | 0.38 | 0.76 | 21 | empty |
| 5 | 89 | 0.38 | 0.76 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 864 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 5NCH · GriE apo form · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0E3URV8
- Elsewhere: RCSB PDB 5NCH · PDBe 5NCH · UniProt A0A0E3URV8
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