MolNFT v1 · #127919 · protein
Complement factor D in complex with the inhibitor (1R,3S,5R)-2-aza- BICYCLO[3.1.0]HEXANE-2,3-dicarboxylic acid 2-[(1-carbamoyl-1H-indol- 3-yl)-amide] 3-[(3-trifluoromethoxy-phenyl)-amide]
5NAW: “Complement factor D in complex with the inhibitor (1R,3S,5R)-2-aza- BICYCLO[3.1.0]HEXANE-2,3-dicarboxylic…”. X-ray diffraction, 1 ligand (8RZ), 1 pocket (best druggability 0.48). MolNFT v1 #127919 on GenesisL1: 3D structure, binding…
- PDB
- 5NAW
- Type
- protein
- Length
- 228 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Complement factor D
- EC
- 3.4.21.46
- UniProt
- P00746
- Ligands
- 8RZ
- Pockets
- 1 · best druggability 0.48
Structure
x-ray diffraction · 1 distinct chain · 9% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Complement factor D (EC 3.4.21.46) | protein | 228 | 9% helix, 36% strand | P00746 |
Ligands and binding sites
- 8RZ · (1~{R},3~{S},5~{R})-~{N}2-(1-aminocarbonylindol-3-yl)-~{N}3-[3-(trifluoromethyloxy)phenyl]-2-azabicyclo[3.1.0]hexane-2,3-dicarboxamide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 176 | 0.48 | 0.77 | 36 | 8RZ |
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00746
- Elsewhere: RCSB PDB 5NAW · PDBe 5NAW · UniProt P00746
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