MolNFT v1 · #127866 · protein + DNA

Crystal structure of drosophila DHX36 helicase in complex with gggttagggt

5N9D · CG9323, isoform a: “Crystal structure of drosophila DHX36 helicase in complex with gggttagggt”. X-ray diffraction, 20 pockets (best druggability 0.89). MolNFT v1 #127866 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5N9D
Type: protein + DNA
Length: 1,741 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CG9323, isoform a; DNA (5'-D(P*GP*GP*GP*TP*TP*AP*GP*GP*GP*T)-3')
EC: 3.6.1.3
UniProt: Q8SWT2
Pockets: 20 · best druggability 0.89

Structure

x-ray diffraction · 3 distinct chains · 47% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	CG9323, isoform a (EC 3.6.1.3)	protein	855	46% helix, 15% strand	Q8SWT2
B	CG9323, isoform a (EC 3.6.1.3)	protein	866	47% helix, 16% strand	Q8SWT2
C, D	DNA (5'-D(PGPGPGPTPTPAPGPGPGPT)-3')	dna	10	—	—

Pockets

20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1071	0.89	0.90	107	empty
2	1188	0.88	0.89	92	empty
3	762	0.83	0.87	67	empty
4	84	0.64	0.90	16	empty
5	96	0.61	0.88	21	empty

Interfaces

3 interfaces between chains.

B–D · 1717 Å² buried · 37 hydrogen bonds · protein-nucleic
A–C · 1695 Å² buried · 33 hydrogen bonds · protein-nucleic
A–B · 510 Å² buried · 7 hydrogen bonds · protein-protein

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8SWT2
Elsewhere: RCSB PDB 5N9D · PDBe 5N9D · UniProt Q8SWT2

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