MolNFT v1 · #127864 · protein

Crystal structure of unliganded human il-17RA

5N9B · Interleukin-17 receptor a: “Crystal structure of unliganded human il-17RA”. X-ray diffraction, 1 ligand (NAG), 1 pocket (best druggability 0.27). MolNFT v1 #127864 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5N9B
Type: protein
Length: 244 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Interleukin-17 receptor a
UniProt: Q96F46
Ligands: NAG
Pockets: 1 · best druggability 0.27

Structure

x-ray diffraction · 1 distinct chain · 5% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Interleukin-17 receptor a	protein	244	5% helix, 50% strand	Q96F46

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	55	0.27	0.73	13	empty

Modifications

Observed in the structure: 6 disulfide, 4 glycan (disulfide, N-glycosylation).

Compared structures

5N9B · Crystal Structure of unliganded human IL-17RA · the same entry in another collection · chain A against A, TM-score 1.00
Q96F46 · AlphaFold monomer V2.0 prediction for interleukin-17 receptor a (Q96F46) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96F46
Elsewhere: RCSB PDB 5N9B · PDBe 5N9B · UniProt Q96F46

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