MolNFT v1 · #127863 · protein + DNA
Crystal structure of drosophila DHX36 helicase in complex with gttagggtt
5N9A · CG9323, isoform a: “Crystal structure of drosophila DHX36 helicase in complex with gttagggtt”. X-ray diffraction, 20 pockets (best druggability 0.88). MolNFT v1 #127863 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5N9A
- Type
- protein + DNA
- Length
- 1,718 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CG9323, isoform a; DNA (5'-D(P*GP*TP*TP*AP*GP*GP*GP*TP*T)-3')
- EC
- 3.6.1.3
- UniProt
- Q8SWT2
- Pockets
- 20 · best druggability 0.88
Structure
x-ray diffraction · 3 distinct chains · 46% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | CG9323, isoform a (EC 3.6.1.3) | protein | 849 | 46% helix, 16% strand | Q8SWT2 |
| B | CG9323, isoform a (EC 3.6.1.3) | protein | 853 | 47% helix, 17% strand | Q8SWT2 |
| C, D | DNA (5'-D(P*GP*TP*TP*AP*GP*GP*GP*TP*T)-3') | dna | 8 | — | — |
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1102 | 0.88 | 0.89 | 87 | empty |
| 2 | 592 | 0.84 | 0.90 | 61 | empty |
| 3 | 880 | 0.83 | 0.85 | 74 | empty |
| 4 | 807 | 0.82 | 0.85 | 71 | empty |
| 5 | 364 | 0.81 | 0.91 | 47 | empty |
Interfaces
3 interfaces between chains.
- B–D · 1343 Ų buried · 25 hydrogen bonds · protein-nucleic
- A–C · 1333 Ų buried · 27 hydrogen bonds · protein-nucleic
- A–B · 500 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 5N9A · Crystal Structure of Drosophila DHX36 helicase in complex with GTTAGGGTT · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8SWT2
- Elsewhere: RCSB PDB 5N9A · PDBe 5N9A · UniProt Q8SWT2
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