MolNFT v1 · #127824 · protein

Crystal structure of FAS1 domain of hyaluronic acid receptor stabilin- 2

5N86 · Stabilin-2: “Crystal structure of FAS1 domain of hyaluronic acid receptor stabilin- 2”. X-ray diffraction, 3 pockets (best druggability 0.51). MolNFT v1 #127824 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5N86
Type: protein
Length: 279 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Stabilin-2
UniProt: Q8WWQ8
Pockets: 3 · best druggability 0.51

Structure

x-ray diffraction · 2 distinct chains · 27% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Stabilin-2	protein	139	27% helix, 28% strand	Q8WWQ8
B	Stabilin-2	protein	140	26% helix, 26% strand	Q8WWQ8

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	89	0.51	0.83	21	empty
2	56	0.43	0.83	15	empty
3	82	0.37	0.76	15	empty

Interfaces

1 interface between chains.

A–B · 699 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

5N86 · Crystal structure of FAS1 domain of hyaluronic acid receptor stabilin-2 · the same entry in another collection · chain A against A, TM-score 1.00
Q8WWQ8 · AlphaFold monomer V2.0 prediction for stabilin-2 (Q8WWQ8) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8WWQ8
Elsewhere: RCSB PDB 5N86 · PDBe 5N86 · UniProt Q8WWQ8

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