Understanding the singular conformational landscape of the tn antigens: sulfur-for- oxygen substitution in the glycosidic linkage provides new insights into molecular recognition by an antibody

Structure

x-ray diffraction · 2 distinct chains.

Ligands and binding sites

• A2G · 2-acetamido-2-deoxy-alpha-D-galactopyranose · sugar · chains I
• NH2 · Amino group · ion · chains H, I
• EDO · 1,2-ethanediol · additive · 7 copies · chains H

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 5N7B · Understanding the singular conformational landscape of the Tn antigens: Sulfur-for… · the same entry in another collection · chain H against H, TM-score 1.00
• P01801 · AlphaFold monomer V2.0 prediction for ig heavy chain V-III region J606 (P01801) · a predicted model of the same protein · chain H against A, TM-score 0.50
• P01727 · AlphaFold monomer V2.0 prediction for ig lambda-1 chain V region S43 (P01727) · a predicted model of the same protein · chain H against A, TM-score 0.48

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P01801
• Every structure of UniProt P01727
• Elsewhere: RCSB PDB 5N7B · PDBe 5N7B · UniProt P01801 · UniProt P01727