MolNFT v1 · #127784 · protein

Retinoschisin R141H mutant

5N6W: “Retinoschisin R141H mutant”. Electron microscopy, 20 pockets (best druggability 0.80). MolNFT v1 #127784 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5N6W
Type: protein
Length: 2,512 residues
Chains: 16
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Retinoschisin
UniProt: O15537
Pockets: 20 · best druggability 0.80

Structure

electron microscopy · 1 distinct chain · 0% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	Retinoschisin	protein	157	0% helix, 17% strand	O15537

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	148	0.80	0.96	30	empty
2	134	0.79	0.96	26	empty
3	135	0.78	0.96	26	empty
4	139	0.78	0.95	27	empty
5	129	0.77	0.95	27	empty

Interfaces

32 interfaces between chains.

C–D · 769 Å² buried · 6 hydrogen bonds · protein-protein
O–P · 769 Å² buried · 6 hydrogen bonds · protein-protein
L–M · 767 Å² buried · 6 hydrogen bonds · protein-protein
A–H · 766 Å² buried · 6 hydrogen bonds · protein-protein
E–F · 766 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 16 disulfide (disulfide).

Compared structures

5N6W · Retinoschisin R141H Mutant · the same entry in another collection · chain P against P, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O15537
Elsewhere: RCSB PDB 5N6W · PDBe 5N6W · UniProt O15537

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