MolNFT v1 · #127706 · protein

Human Fab fragment 10C3 against nhba from neisseria meningitidis

5N4J · Light chain: “Human Fab fragment 10C3 against nhba from neisseria meningitidis”. X-ray diffraction, 3 pockets (best druggability 0.47). MolNFT v1 #127706 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5N4J
Type: protein
Length: 420 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Light chain; Heavy chain
Pockets: 3 · best druggability 0.47

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	Light chain	protein	211	7% helix, 51% strand	—
H	Heavy chain	protein	209	7% helix, 52% strand	—

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	214	0.47	0.74	32	empty
2	55	0.29	0.74	12	empty
3	55	0.27	0.74	16	empty

Interfaces

1 interface between chains.

L–H · 1566 Å² buried · 17 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

5N4J · human Fab fragment 10C3 against NHBA from Neisseria meningitidis · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 5N4J · PDBe 5N4J

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