MolNFT v1 · #127648 · protein

Sulfolobus solfataricus tryptophan synthase a

5N2P · Tryptophan synthase alpha chain: “Sulfolobus solfataricus tryptophan synthase a”. X-ray diffraction, 1 ligand (CL), 1 pocket (best druggability 0.76). MolNFT v1 #127648 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5N2P
Type: protein
Length: 241 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tryptophan synthase alpha chain
EC: 4.2.1.20
UniProt: P50382
Ligands: CL
Pockets: 1 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 47% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tryptophan synthase alpha chain (EC 4.2.1.20)	protein	241	47% helix, 15% strand	P50382

Ligands and binding sites

CL · Chloride ion · ion · chains A
PG4 · Tetraethylene glycol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	383	0.76	0.86	49	PG4, CL

Compared structures

5N2P · Sulfolobus solfataricus Tryptophan Synthase A · the same entry in another collection · chain A against A, TM-score 1.00
P50382 · AlphaFold monomer V2.0 prediction for tryptophan synthase alpha chain (P50382) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P50382
Elsewhere: RCSB PDB 5N2P · PDBe 5N2P · UniProt P50382

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