MolNFT v1 · #127644 · protein
Crystal structure of the second bromodomain of human BRD2 in complex with a tetrahydroquinoline analogue
5N2L: “Crystal structure of the second bromodomain of human BRD2 in complex with a tetrahydroquinoline analogue”. X-ray diffraction, 2 ligands (8J2, SO4). MolNFT v1 #127644 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5N2L
- Type
- protein
- Length
- 433 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P25440
- Ligands
- 8J2, SO4
Structure
x-ray diffraction · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | — | protein | 109 | — | P25440 |
| C | — | protein | 107 | — | P25440 |
| D | — | protein | 108 | — | P25440 |
Ligands and binding sites
- 8J2 · propan-2-yl ~{N}-[(2~{S},4~{R})-6-(3-acetamidophenyl)-1-ethanoyl-2-methyl-3,4-dihydro-2~{H}-quinolin-4-yl]carbamate · ligand · 4 copies · chains A, B, C, D
- SO4 · Sulfate ion · ion · 6 copies · chains A, B, C, D
- EDO · 1,2-ethanediol · additive · 4 copies · chains A, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5N2L · Crystal structure of the second bromodomain of human BRD2 in complex with a… · the same entry in another collection · chain D against D, TM-score 1.00
- P25440 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 2 (P25440) · a predicted model of the same protein · chain C against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P25440
- Elsewhere: RCSB PDB 5N2L · PDBe 5N2L · UniProt P25440
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