MolNFT v1 · #127545 · protein
Crystal structure of the myosin chaperone unc-45 from C. elegans (alternative conformation)
5MZU: “Crystal structure of the myosin chaperone unc-45 from C. elegans (alternative conformation)”. X-ray diffraction, 15 pockets (best druggability 0.79). MolNFT v1 #127545 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5MZU
- Type
- protein
- Length
- 869 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Unc-45
- UniProt
- G5EG62
- Pockets
- 15 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 68% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Unc-45 | protein | 869 | 68% helix, 0% strand | G5EG62 |
Pockets
15 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 746 | 0.79 | 0.83 | 86 | empty |
| 2 | 530 | 0.77 | 0.84 | 79 | empty |
| 3 | 491 | 0.69 | 0.79 | 49 | empty |
| 4 | 506 | 0.68 | 0.79 | 60 | empty |
| 5 | 375 | 0.68 | 0.81 | 35 | empty |
Modifications
Observed in the structure: 21 modified (engineered).
Compared structures
- 5MZU · Crystal structure of the myosin chaperone UNC-45 from C. elegans (alternative… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G5EG62
- Elsewhere: RCSB PDB 5MZU · PDBe 5MZU · UniProt G5EG62
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