MolNFT v1 · #127522 · protein

Crystal structure of full-lengh csfv NS3/4A

5MZ4 · Genome POLYPROTEIN,GENOME polyprotein: “Crystal structure of full-lengh csfv NS3/4A”. X-ray diffraction, 20 pockets (best druggability 0.67). MolNFT v1 #127522 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5MZ4
Type: protein
Length: 1,383 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Genome POLYPROTEIN,GENOME polyprotein
EC: 3.4.22.-, 3.4.21.113, 3.6.1.15, 3.6.4.13, 2.7.7.48
UniProt: P19712
Pockets: 20 · best druggability 0.67

Structure

x-ray diffraction · 2 distinct chains · 27% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Genome POLYPROTEIN,GENOME polyprotein (EC 3.4.22.-, 3.4.21.113, 3.6.1.15, 3.6.4.13, 2.7.7.48)	protein	704	27% helix, 31% strand	P19712
B	Genome POLYPROTEIN,GENOME polyprotein (EC 3.4.22.-, 3.4.21.113, 3.6.1.15, 3.6.4.13, 2.7.7.48)	protein	679	28% helix, 29% strand	P19712

Pockets

20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	524	0.67	0.78	44	empty
2	230	0.66	0.83	35	empty
3	191	0.65	0.85	29	empty
4	206	0.64	0.83	35	empty
5	255	0.59	0.79	31	empty

Interfaces

1 interface between chains.

A–B · 2479 Å² buried · 63 hydrogen bonds · protein-protein

Compared structures

5MZ4 · Crystal Structure of full-lengh CSFV NS3/4A · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P19712
Elsewhere: RCSB PDB 5MZ4 · PDBe 5MZ4 · UniProt P19712

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