MolNFT v1 · #127373 · protein
Structure of deformed wing virus, a honeybee pathogen
5MUP · VP1: “Structure of deformed wing virus, a honeybee pathogen”. Electron microscopy, 1 ligand (U5P), 8 pockets (best druggability 0.65). MolNFT v1 #127373 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5MUP
- Type
- protein
- Length
- 840 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- VP1; VP2; VP3
- UniProt
- L0CTV4, E0YTW0, Q7TG18
- Ligands
- U5P
- Pockets
- 8 · best druggability 0.65
Structure
electron microscopy · 3 distinct chains · 10% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | VP1 | protein | 239 | 12% helix, 25% strand | L0CTV4 |
| B | VP2 | protein | 248 | 13% helix, 31% strand | E0YTW0 |
| C | VP3 | protein | 353 | 7% helix, 29% strand | Q7TG18 |
Ligands and binding sites
- U5P · Uridine-5'-monophosphate · ligand · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 365 | 0.65 | 0.79 | 54 | empty |
| 2 | 158 | 0.48 | 0.77 | 30 | empty |
| 3 | 77 | 0.39 | 0.79 | 18 | empty |
| 4 | 116 | 0.39 | 0.74 | 15 | empty |
| 5 | 56 | 0.37 | 0.79 | 12 | empty |
Interfaces
3 interfaces between chains.
- A–C · 4831 Ų buried · 63 hydrogen bonds · protein-protein
- A–B · 1469 Ų buried · 26 hydrogen bonds · protein-protein
- B–C · 1399 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 5MUP · Structure of deformed wing virus, a honeybee pathogen · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt L0CTV4
- Every structure of UniProt E0YTW0
- Every structure of UniProt Q7TG18
- Elsewhere: RCSB PDB 5MUP · PDBe 5MUP · UniProt L0CTV4 · UniProt E0YTW0 · UniProt Q7TG18
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