MolNFT v1 · #127365 · protein
Crystal structure of an amyloidogenic light chain dimer H7
5MUH: “Crystal structure of an amyloidogenic light chain dimer H7”. X-ray diffraction, 5 pockets (best druggability 0.57). MolNFT v1 #127365 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5MUH
- Type
- protein
- Length
- 376 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Light chain dimer
- Pockets
- 5 · best druggability 0.57
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Light chain dimer | protein | 194 | 7% helix, 50% strand | — |
| B | Light chain dimer | protein | 182 | 5% helix, 47% strand | — |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 428 | 0.57 | 0.74 | 44 | empty |
| 2 | 62 | 0.34 | 0.77 | 18 | empty |
| 3 | 86 | 0.32 | 0.73 | 22 | empty |
| 4 | 75 | 0.31 | 0.74 | 20 | empty |
| 5 | 62 | 0.31 | 0.75 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1375 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 5MUH · Crystal structure of an amyloidogenic light chain dimer H7 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 5MUH · PDBe 5MUH
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