MolNFT v1 · #127255 · protein

Crystal structure of the dbd domain of human GRHL2

5MR7 · Grainyhead-like protein 2 homolog: “Crystal structure of the dbd domain of human GRHL2”. X-ray diffraction, 4 pockets (best druggability 0.71). MolNFT v1 #127255 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5MR7
Type: protein
Length: 384 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Grainyhead-like protein 2 homolog
UniProt: Q6ISB3
Pockets: 4 · best druggability 0.71

Structure

x-ray diffraction · 2 distinct chains · 15% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Grainyhead-like protein 2 homolog	protein	190	14% helix, 41% strand	Q6ISB3
B	Grainyhead-like protein 2 homolog	protein	194	15% helix, 40% strand	Q6ISB3

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	532	0.71	0.80	53	empty
2	63	0.36	0.78	17	empty
3	52	0.34	0.78	16	empty
4	59	0.29	0.74	15	empty

Interfaces

1 interface between chains.

A–B · 854 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

5MR7 · Crystal structure of the DBD domain of human Grhl2 · the same entry in another collection · chain A against A, TM-score 1.00
Q6ISB3 · AlphaFold monomer V2.0 prediction for grainyhead-like protein 2 homolog (Q6ISB3) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6ISB3
Elsewhere: RCSB PDB 5MR7 · PDBe 5MR7 · UniProt Q6ISB3

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.